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- Klinische Studien
- Produkte in der Entwicklung
- Novartis-Stiftung für therapeutische Forschung
- Phasen der Arzneimittel- entwicklung
Publikationen aus geförderten Projekten
Förderthematik der Ausschreibung des Jahres 2006:
„(Pro)-Renin und Reninrezeptor – pathophysiologische Bedeutung jenseits der Angiotensin II-Synthese“
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Fischer R et al. (Müller D N): Dietary n-3 Polyunsaturated Fatty Acids and Direct Renin Inhibition Improve Electrical Remodeling in a Model of High Human Renin Hypertension: Hypertension online Dez 24 (2007)
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Müller D N et al. : (Pro)Renin Receptor Peptide Inhibitor "Handle-Region" Peptide Does Not Affect Hypertensive Nephrosclerosis in Goldblatt Rats: Hypertension online Jan 22 (2008)
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Feldt S et al. (Müller D N): Prorenin and Renin-Induced Extracellular Signal Regulated Kinase 1/2 Activation in Monocytes Is Not Blocked by Aliskiren or the Handle-Region Peptide: Hypertension online Jan 22 (2008)
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Feldt S et al. (Müller D N ): The Putative (Pro)renin Receptor Blocker HRP Fails to Prevent (Pro)renin Signaling: J Am Soc Nephrol Jan 30 (2008)
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Zöllinger A et al. (Stühmer T, Bargou R C): Combined functional and molecular analysis of tumor cell signaling defines two distinct myeloma subgroups: Akt-dependent and Akt-independent multiple myeloma: Blood online Jul 17 (2008)
Förderthematik der Ausschreibung des Jahres 2005:
„Transkriptionale Regulation und Inflammation bei Arteriosklerose und Adipositas“
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Thum T et al. (Bauersachs J): Bone marrow molecular alterations after myocardial infarction: Impact on endothelial progenitor cells: Cardiovascular Research 70 (2006) 50-60
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Thum T et al. (Bauersachs J): Endothelial Nitric Oxide Synthase Uncoupling Impairs Endothelial Progenitor Cell Mobilization and Function in Diabetes: Diabetes 56 (2007) 666-674
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Thum T et al. (Bauersachs J): Differential Effects of Organic Nitrates on Endothelial Progenitor Cells Are Determined by Oxidative Stress: Arterioscler Thromb Vasc Biol. (2007) 27, 748-754
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Thum T et al. (Bauersachs J): Age-Dependent Impairment of Endothelial Progenitor Cells Is Corrected by Growth Hormone Mediated Increase of Insulin-Like Growth Factor-1: Circulation Research (2007) 100, 434-443
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Daub K et al. (Langer H, May A E, Gawaz M): Platelets induce differentiation of human CD34+ progenitor cells into foam cells and endothelial cells: The FASEB Journal (2006) 20, E1-E10
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Langer H F et al. (May A E, Gawaz M): Platelets Recruit Human Dendritic Cells Via Mac-1/ JAM-C Interaction and Modulate Dendritic Cell Function In Vitro: Arterioscler Thromb Vasc Biol. (2007) 27, 1-9
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Lindemann S et al. (Gawaz M): Molecular pathways used by platelets to initiate and accelerate atherogenesis: Current Opinion in Lipidology (2007) 18, 566-573
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Schmidt R et al. (May A E, Gawaz M): Extracellular Matrix Metalloproteinase Inducer (CD147) Is a Novel Receptor on Platelets, Activates Platelets, and Augments Nuclear Factor kB-Dependent Inflammation in Monocytes: Circ Res. (2008) 102, 1-8
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Stellos K et al. (Langer H, May A E, Gawaz M): Platelet-Derived Stromal Cell Derived Factor-1 Regulates Adhesion and Promotes Differentiation of Human CD34+Cells to Endothelial Progenitor Cells: Circulation (2008) 117, 206-215
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Schönberger T et al. (Gawaz M): The immunoadhesin glycoprotein VI-Fc regulates arterial remodeling after mechanical injury in ApoE-/- mice: Cardiovascular Research (2008) accepted
Förderthematik der Ausschreibung des Jahres 2004:
„Transkriptionale Regulation und Inflammation bei Arteriosklerose und Adipositas“
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Schroeter M R et al. (Konstantinides S, Schäfer K): Leptin Enhances the Recruitment of Endothelial Progenitor Cells Into Neointimal Lesions After Vascular Injury by Promoting Integrin-Mediated Adhesion: Circ. Res. online Jul 24 (2008)
Förderthematik der Ausschreibung des Jahres 2003:
„Kardiale Regeneration mittels Stamm- / Progenitorzellen“
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Eschenhagen T, Zimmermann WH: Engineering myocardial tissue: Circ Res 97:1220-1231 (2005)
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Naito H et al. (Eschenhagen T, Zimmermann WH): Optimizing engineered heart tissue for therapeutic applications as surrogate heart muscle: Circulation 114:I72-78 (2006)
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Zimmermann WH et al. (Eschenhagen T): Heart muscle engineering: an update on cardiac muscle replacement therapy: Cardiovasc Res 71:419-429 (2006)
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Zimmermann WH, Eschenhagen T: Embryonic stem cells for cardiac muscle engineering: Trends Cardiovasc Med 17:134-140 (2007)
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Yildirim Y et al. (Eschenhagen T, Zimmermann WH): Development of a Biological Ventricular Assist Device (BioVAD): Preliminary Data from a Small Animal Model: Circulation 116:I16-23 (2007)
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Zimmermann WH et al. (Eschenhagen T): Cardiac tissue engineering: a clinical perspective: Future Cardiol 3:435-445 (2007)
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M. Hofmann et al. (K. C. Wollert, G.P. Meyer, H. Drexler): Monitoring of Bone Marrow Cell Homing into the Infarcted Human Myocardium: Circulation 2005;111:2198-2202
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Keiper T et al. (Iserman B, Chavakis T): The role of junctional adhesion molecule-C (JAM-C) in oxidized LDL-mediated leukocyte recruitment: FASEB J. 2005 Sep 29
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T. Chavakis et al.: Angiostatin is a Novel Anti-inflammatory Factor by Inhibiting Leukocyte Recruitment: Blood; 105:1036-43, 2005
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Keiper T, Chavakis T et al.: The role of junctional adhesion molecules in cell-cell interactions: Histol. Histopathol. 20:197-203, 2005
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Sotirios N et al. (Berend Isermann, Triantafyllos Chavakis): Lipoprotein(a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-1 integrin: FASEB J. 2006; 20(3):559-61
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Berend Isermann et al. (Triantafyllos Chavakis): Activated Protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis: Nature Medicine: in press
Förderthematik der Ausschreibung des Jahres 2002:
- Carolin Schmittwolf et al. (Albrecht M Müller): In vivo haematopoietic activity is induced in neuroshere cells by chromatin-modifying agents: The EMBO Journal (2005) 24, 554-566
- Dürr, M.; Harder, F.; Müller, A.M. (2006): Developmental potential of somatic stem cells following injection into murine blastocysts. In: Ho, Hoffman, Zanjani (Eds.) Stem Cell Transplantation: WILEY-VCH
- Klinz FJ et al. (Bloch W): Phospho-eNOS Ser-114 in human mesenchymal stem cells: constitutive phosphorylation, nuclear localization and upregulation during mitosis: Eur J Cell Biol (2005) 84:809-18
- Arnhold S et al. (Bloch W): Human bone marrow stroma cells display certain neural characteristics and integrate in the subventricular compartment after injection into the liquor system: Eur J Cell Biol 2006 Jun;85(6):551-65. Epub 2006 May 2
- Brixius K et al. (Bloch W): Endothelial progenitor cells: a new target for the prevention of cardiovascular disease: Eur J Cardiovasc Prev Rehabil. 2006 Oct;13(5):705-10. Review.
- Schmidt A et al. (Schwinger R, Mehlhorn U, Bloch W): Mesenchymal stem cells transmigrate over the endothelial barrier: European Journal of Cell Biology 85 (2006) 1179-1188
- Schmidt A et al. (Mehlhorn U, Schwinger R, Bloch W): Basic Fibroblast Growth Factor Controls Migration in Human Mesenchymal Stem Cells: Stem Cells 2006; 24;1750-1758
- Ladage D et al. (Bloch W): Mesenchymal stem cells induce endothelial activation via paracine mechanisms: Endothelium. 2007 Mar-Apr;14(2):53-63.
- Schmidt A et al. (Bloch W): Endothelial Precursor Cell Migration During Vasculogenesis: Circ. Res. 2007; 101;125-136
- Funcke F et al. (Bloch W): Characterisation of the interaction between circulating and in vitro cultivated endothelial progenitor cells and the endothelial barrier: European Journal of Cell Biology: in press
- Rotter N et al. (Lang S): Isolation and Characterization of Adult Stem Cells from Human Salivary Glands: Stem Cells and Development: in press
Förderthematik der Ausschreibung des Jahres 2001:
“Molekulares Targeting zur Tumorzell- spezifischen Therapie“
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A. Kröger et al. (H. Hauser): Activities of IRF 1. :J Interferon Cytokine Res. 22:5-14 (2002)
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A. Kröger et al. (H. Hauser): IRF-1 reverts the transformed phenotype of oncogenically transformed cells in vitro and in vivo: Oncogene (2003) 22, 1045-1056
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A. Wichert et al. (P. S. Holm): Glypican-3 is involved in cellular protection against mitoxantrone in gastric carcinoma cells: Oncogene (2004) 23, 945-955
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P. S. Holm et al. (B. Gänsbacher): Multidrug-resistant Cancer Cells Facilitate E1-independent Adenoviral Replication: Impact for Cancer Gene Therapy: Cancer Research 64, 322-328, January 1, 2004
„Hämostaseologie / Antithrombotische Strategien“
- Chavakis T et al. (Preissner KT): Hämostatic factors occupy new territory: the role of the urokinase receptor system and kininogen in inflammation: Biochem Soc Trans. 2002; 30: 168-173
- Chavakis T et al. (Preissner KT): Inhibition of platelet adhesion and aggregation by a defined region (Gly-486-Lys-502) of high molecular weight kininogen: J Biol Chem: 2002; 277: 23157-23164
- Chavakis T et al. (Preissner KT): A novel antithrombotic role for high molecular weight kininogen as inhibitor of plasminogen activator inhibitor-1 function: J Biol Chem. 2002; 277:32677-32682
- Al-Fakhri N et. al. (Chavakis T, Preissner KT): Induction of apoptosis in vascular cells by plasminogen activator inhibitor-1 and high molecular weight kininogen correlates with their anti-adhesive properties: Biol Chem. 2003; 384:423-435
- Chavakis T et al. (Preissner KT): High molecular weight kininogen regulates platelet-leukocyte interactions by bridging Mac-1 and glycoprotein 1b: J Biol Chem. 2003; 278: 45375- 45381
- Chavakis T, Preissner KT: Potential pharmacological applications of the antithrombotic molecule high molecular weight kininogen: Curr Vasc Pharmacol. 2003;1: 59-64
- Kanse SM et al. (Chavakis T, Preissner KT): Variability in the expression of urokinase receptor (CD 87) mutants on cells: relevance to sell adhesion: Cell. Biochem. Funct. 2004; 22:257-264
- Wetzel A et al. (Chavakis T, Preissner KT): Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18): J. Immunol. 2004; 172:3850-3859
- Chavakis T et al. (Preissner KT): The junctional adhesion molecule-C promotes neutrophil transendothelial migration in vitro and in vivo: J. Biol. Chem. 2004; 279: 55602-55608
- Chavakis T et al. (Preissner KT): Regulation of neovascularization by human neutrophil peptides (a-defensins): a link between inflammation an angiogenesis: FASEB J. 2004; 18: 1306-1308
- Economopoulou M et al. (Chavakis T, Preissner KT): Inhibition of pathologic retinal neovascularization by alpha-defensins: Blood 2005; 106: 3831-3838
Förderthematik der Ausschreibung des Jahres 2000:
„Molekulares Targeting zur Tumorzell-spezifischen Therapie“
- Nagel-Wolfrum K et al. (Groner B):The Interaction of Specific Peptide Aptamers With the DNA Binding Domain and the Dimerization Domain of the Transcription Factor Stat3 Inhibits Transactivation and Induces Apoptosis in Tumor Cells: Molecular Cancer Research 2, 170-182, 2004
- Gottstein C et al.: Vascular targeting using STIAs (specific thrombosis inducing agents) for the treatment of Hodgkin's lymphoma: Leukemia & Lymphoma 42/2: 90, 2001
- Philipp J et al. (Gottstein C): Induction of selective tumor vessel thrombosis in a mouse model for Hodgkin's lymphoma: Onkologie 24/6: 82, 2001
- Philipp J et al. (Engert A, Gottstein C): Soluble tissue factor induces coagulation on tumor endothelial cells in vivo if coadministered with low-dose lipopolysaccharides: Art Thromb Vasc Biol 23: 905-10, 2003
- Rubio I, et al.: Quantification of absolute Ras-GDP/GTP levels by HPLC separation of Ras-bound (32P)-labelled nucleotides: . J. Biochem. Biophys. Methods 58:111-117 (2004)
- R. Pusch, I. Rubio: Echtzeit-Visualisierung kleiner GTPasen in lebenden Zellen: Laborwelt 6, 4-10 (2005)
M. Augsten et.al. (Friedrich K, Rubio I): Live-cell imaging of endogenous Ras-GTP illustrates predominant Ras activation at the plasma membrane: EMBO Rep. 7:46-51 (2006)
Förderthematik der Ausschreibung des Jahres 1999:
„Beeinflussung von Signaltransduktion und Apoptose als molekulare Strategien in der Hämato-Onkologie
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Siegmund B et al. (Meinhard G, Emmerich B, Endres S): Phosphodiesterase type 4 inhibitor suppresses expression of anti-apoptotic members of the Bcl-2 family in B-CLL cells and induces caspase-dependent apoptosis: Leukemia (2001) 15, 1564-1571
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Warmuth M et al. (Hallek M): Dual-specific Src and Abl kinase inhibitors, PP1 and CGP76030, inhibit growth and survival of cells expressing imatinib mesylate-resistant Bcr-Abl kinases: Blood (2003) 101 (2), 664-672
NIBR
Die Novartis Institutes for BioMedical Research (NIBR) bilden das globale Forschungsnetzwerk von Novartis.
Soziale Verantwortung
Soziale Verantwortung bei Novartis
Ein Überblick unserer Aktivitäten im Jahr 2006
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